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The Minx remained in production until 1962, after the 1961 introduction of Isuzu's first own car, the Bellel.
Being a small producer making cars which were somewhat too large and pricey for the Japanese market at the time, Isuzu spent some time looking for a commercial partner.
Isuzu's then president Toshio Okamoto then initiated a collaboration with small-car expert Suzuki to develop a global small car for GM, the S-car.
Following on from this, in 1985 Isuzu and GM established the IBC Vehicles venture in the United Kingdom, producing locally built versions of Isuzu and Suzuki light vans (the Isuzu Fargo and Suzuki Carry); to be sold in the European market under Vauxhall's Bedford brand.
This OEM tie-up occurred alongside the establishment of SIA (Subaru-Isuzu Automotive), an American joint venture with Fuji Heavy Industries (the parent company of Subaru).
Shortly afterwards, the Lafayette, Indiana plant became operational.
Isuzu has assembly and manufacturing plants in Fujisawa, as well as in the Tochigi and Hokkaidō prefectures.
During this period Isuzu also developed a worldwide presence as an exporter of diesel engines, with their powerplants in use by Opel/Vauxhall, Land Rover, Hindustan, and many others.
Two Isuzu model lines (Gemini, Impulse) were marketed as part of the Geo division (Spectrum, Storm) when it was initially launched as a Chevrolet subsidiary.
It was sold in the United States as Buick's Opel by Isuzu, and in Australia as the Holden Gemini.
As a result of the collaboration, certain American GM products are sold to Japanese customers through Isuzu dealerships.
In 1981 Isuzu began selling consumer and commercial vehicles under their own brand in the United States.